TB-500
Thymosin Beta-4 fragment — researched for actin regulation and tissue repair.
Purity
98%+ (per source specifications)
Form
Lyophilised Powder
Storage
-20°C lyophilised · store at 2–8°C once reconstituted
CAS Number
77591-33-4
Mol. Weight
889.0 g/mol
£15.99
Free UK delivery
About TB-500
What it is
TB-500 is a synthetic version of a short region of Thymosin Beta-4, a protein found in almost every human cell and in high concentration in wound fluid and platelets. Rather than the whole 43-amino-acid protein, this is the active binding fragment, which makes it cheaper to synthesise and easier to keep in solution.
How it is understood to work
Its defining property is binding to G-actin. Actin is the protein that gives a cell its skeleton and lets it change shape and move, and by sequestering the free monomer form, this fragment influences how readily actin filaments assemble and disassemble. Cell motility depends on exactly that cycle, which is why it appears so often in migration and remodelling research.
What research has looked at
Laboratory work has examined cell migration, endothelial cell behaviour, corneal and dermal wound models, and cardiac tissue models. Interest largely follows from the actin-binding mechanism rather than from any single dramatic finding. As with everything on this site, it is supplied for in-vitro research and has no established human therapeutic use.
Handling and storage
Lyophilised and hygroscopic — it will pull moisture from the air, so let the vial reach room temperature before opening or you will condense water into the powder. Reconstitute gently down the side of the vial rather than directly onto the pellet; the actin-binding region is a flexible chain and vigorous shaking encourages aggregation. Refrigerate once in solution.
Supplied for in-vitro laboratory research only. Nothing above describes a dose, a protocol, or a use in humans or animals, and none of these compounds is a licensed medicine in the UK.
Certificate of Analysis
Purity (HPLC)
99.6%
- Batch
- 26031901
| Test | Specification | Result |
|---|---|---|
| Appearance | White powder | White powder |
| Identity (mass spectrometry) | 889.0 ± 1.0 | 888.3 |
| Purity (HPLC) | Not less than 98.0% | 99.6% |
| Bacterial endotoxins | Not more than 10 EU/mg | Less than 10 EU/mg |
| Water content (Karl Fischer) | Not more than 8.0% | 4.9% |
| Residual solvents | Within limits | Conforms |
This batch of TB-500 complies with specification. Figures are taken from the manufacturer certificate of analysis for this batch.
Research Information
TB-500 is the synthetic version of thymosin β-4, a naturally occurring 43-amino-acid peptide, studied for its role in tissue research. Researchers are interested in how it interacts with actin — the protein that gives cells their structure and mobility — and in pathways involved in cell migration, angiogenesis (new blood vessel formation), and inflammation. Most published work has used in-vitro cell-migration assays and tissue-repair models to examine these mechanisms.
Research areas
- Actin sequestration studies
- Cell migration and chemotaxis research
- Angiogenesis pathway studies
- Inflammatory marker cell-model research
Analytical methods
Identity and purity are typically confirmed at source by high-performance liquid chromatography (HPLC) and mass spectrometry.
Storage and handling
Store lyophilised at -20°C, away from moisture and direct light. Once reconstituted, store at 2–8°C and use within the timeframe specified on the source datasheet.
For Research Use Only. Not for human or veterinary use.
Batch tested
Every batch is tested for identity and purity, and we publish the certificate.
UK dispatch
UK-stocked. Orders placed before 2pm dispatch the same business day via Royal Mail Tracked 24. Free UK shipping on every order. We ship to UK addresses only.