Sermorelin
Synthetic 29-amino-acid analogue of human GHRH supplied for in-vitro GHRH receptor research.
Purity
98%+ (per source specifications)
Form
Lyophilised Powder
Storage
-20°C lyophilised · store at 2–8°C once reconstituted
CAS Number
86168-78-7
Mol. Weight
3357.9 g/mol
£31.99
Free UK delivery
About Sermorelin
What it is
Sermorelin is GHRH(1-29) — the first twenty-nine amino acids of growth-hormone-releasing hormone, which is the shortest fragment retaining full biological activity of the parent hormone. It was formerly marketed as a medicine under the name Geref, since discontinued.
How it is understood to work
It binds the GHRH receptor on pituitary somatotrophs. Because it acts on the pituitary rather than supplying growth hormone directly, release remains subject to the body's own regulation, including negative feedback through somatostatin. That preserved feedback is a large part of why the fragment is used as a research tool.
What research has looked at
Pituitary function testing, endocrine research on the GH axis, and comparative work against modified analogues such as CJC-1295, which were developed specifically to overcome its very short half-life.
Handling and storage
Short-lived in solution relative to the modified analogues. Reconstitute what is needed, keep refrigerated, and do not expect extended stability.
Supplied for in-vitro laboratory research only. Nothing above describes a dose, a protocol, or a use in humans or animals, and none of these compounds is a licensed medicine in the UK.
Research Information
Sermorelin is a synthetic 29-amino-acid peptide representing the active N-terminal fragment of human growth-hormone releasing hormone (GHRH 1-29). It's studied for its role in GHRH receptor research. Because it's effectively the minimal active GHRH sequence, researchers use it as a reference compound for studying receptor binding and signalling without the rest of the native 44-amino-acid GHRH molecule. Most published work has used pituitary cell models to examine binding affinity and downstream cyclic AMP signalling.
Research areas
- GHRH receptor binding affinity studies
- Pituitary cell-line research
- Minimal-active-sequence reference studies
- Cyclic AMP signalling pathway research
Analytical methods
Identity and purity are typically confirmed at source by high-performance liquid chromatography (HPLC) and mass spectrometry.
Storage and handling
Store lyophilised at -20°C, away from moisture and direct light. Once reconstituted, store at 2–8°C and use within the timeframe specified on the source datasheet.
For Research Use Only. Not for human or veterinary use.
Batch tested
Every batch is tested for identity and purity, and we publish the certificate.
UK dispatch
UK-stocked. Orders placed before 2pm dispatch the same business day via Royal Mail Tracked 24. Free UK shipping on every order. We ship to UK addresses only.