PT-141 (Bremelanotide)
Synthetic α-MSH-derived heptapeptide supplied for in-vitro MC3R/MC4R receptor research.
Purity
98%+ (per source specifications)
Form
Lyophilised Powder
Storage
-20°C lyophilised · store at 2–8°C once reconstituted
CAS Number
189691-06-3
Mol. Weight
1025.2 g/mol
£21.99
Free UK delivery
About PT-141 (Bremelanotide)
What it is
PT-141, or bremelanotide, is a melanocortin receptor agonist derived from Melanotan II. In the United States it is a licensed medicine sold as Vyleesi. As with MT-1, the licensed pharmaceutical product is a specific preparation for a specific approved indication and is not what is supplied here.
How it is understood to work
It acts on melanocortin receptors, with activity at MC4R and MC3R considered central. Unlike its parent compound it produces little pigmentary effect. Its research interest lies in acting on central nervous system pathways rather than on the vascular system, which distinguishes it mechanistically from other compounds studied in the same broad area.
What research has looked at
Melanocortin receptor pharmacology, central nervous system signalling, and animal behavioural models. Receptor-binding and selectivity work forms a large part of the literature.
Handling and storage
Lyophilised. Reconstitute gently with bacteriostatic water, refrigerate, protect from light. Standard peptide precautions.
Supplied for in-vitro laboratory research only. Nothing above describes a dose, a protocol, or a use in humans or animals, and none of these compounds is a licensed medicine in the UK.
Research Information
PT-141 (Bremelanotide) is a synthetic 7-amino-acid analogue of α-melanocyte stimulating hormone (α-MSH), studied for its role in melanocortin receptor research. Unlike the older MT-2, it acts primarily on MC4R rather than MC1R. Researchers are interested in melanocortin receptors because they're involved in pathways linked to sexual behaviour, appetite regulation, and inflammation in cell-culture and animal-model studies. Published work has used cell lines expressing the different melanocortin receptor subtypes to examine selectivity and downstream signalling.
Research areas
- Melanocortin receptor (MC3R/MC4R) selectivity studies
- cAMP signalling pathway research
- Receptor subtype comparison studies
- Melanocortin-related neuropeptide research
Analytical methods
Identity and purity are typically confirmed at source by high-performance liquid chromatography (HPLC) and mass spectrometry.
Storage and handling
Store lyophilised at -20°C, away from moisture and direct light. Once reconstituted, store at 2–8°C and use within the timeframe specified on the source datasheet.
For Research Use Only. Not for human or veterinary use.
Batch tested
Every batch is tested for identity and purity, and we publish the certificate.
UK dispatch
UK-stocked. Orders placed before 2pm dispatch the same business day via Royal Mail Tracked 24. Free UK shipping on every order. We ship to UK addresses only.