MOTS-c
Synthetic 16-amino-acid mitochondrial-derived peptide supplied for in-vitro metabolic research.
Purity
98%+ (per source specifications)
Form
Lyophilised Powder
Storage
-20°C lyophilised · store at 2–8°C once reconstituted
CAS Number
1627580-64-6
Mol. Weight
2174.6 g/mol
£26.99
Free UK delivery
About MOTS-c
What it is
MOTS-c is unusual: a sixteen-amino-acid peptide encoded not by the cell nucleus but by mitochondrial DNA. It belongs to a small class called mitochondrial-derived peptides, discovered only in the last fifteen years, and its existence complicated the long-held assumption that mitochondrial DNA coded almost exclusively for components of the respiratory chain.
How it is understood to work
Laboratory work has focused on AMP-activated protein kinase, the enzyme cells use as a fuel gauge, and on the folate-methionine cycle. It has also been observed to translocate to the nucleus under metabolic stress and influence gene expression there, which makes it a signal travelling from mitochondrion to nucleus rather than the other way round.
What research has looked at
Research has examined glucose handling in cell and animal models, exercise physiology, and metabolic stress responses. It is a comparatively young area and the field is still establishing basics.
Handling and storage
Lyophilised, reconstitute with bacteriostatic water, refrigerate. Standard peptide precautions: room temperature before opening, gentle reconstitution, no vigorous agitation.
Supplied for in-vitro laboratory research only. Nothing above describes a dose, a protocol, or a use in humans or animals, and none of these compounds is a licensed medicine in the UK.
Certificate of Analysis
Purity (HPLC)
99.4%
- Batch
- 26030503-04
| Test | Specification | Result |
|---|---|---|
| Appearance | White or off-white powder | White powder |
| Identity (mass spectrometry) | 2174.6 ± 1.0 | 2174.0 |
| Purity (HPLC) | Not less than 98.0% | 99.4% |
| Bacterial endotoxins | Less than 10 EU/mg | Less than 3 EU/mg |
| Water content (Karl Fischer) | Not more than 8.0% | 3.3% |
| Residual solvents | Within limits | Conforms |
This batch of MOTS-c complies with specification. Figures are taken from the manufacturer certificate of analysis for this batch.
Research Information
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene, studied for its role in metabolic and mitochondrial research. Researchers are interested in how mitochondrial-derived peptides communicate with the nucleus and regulate metabolic pathways — particularly insulin sensitivity and glucose handling — in cell-culture studies. Most published work has used myocyte and adipocyte cell lines to examine AMPK pathway activation and exercise-related metabolic adaptation models.
Research areas
- AMPK signalling pathway studies
- Mitochondrial-derived peptide (MDP) research
- Insulin sensitivity cell models
- Myocyte and adipocyte metabolic research
Analytical methods
Identity and purity are typically confirmed at source by high-performance liquid chromatography (HPLC) and mass spectrometry.
Storage and handling
Store lyophilised at -20°C, away from moisture and direct light. Once reconstituted, store at 2–8°C and use within the timeframe specified on the source datasheet.
For Research Use Only. Not for human or veterinary use.
Batch tested
Every batch is tested for identity and purity, and we publish the certificate.
UK dispatch
UK-stocked. Orders placed before 2pm dispatch the same business day via Royal Mail Tracked 24. Free UK shipping on every order. We ship to UK addresses only.