KPV
Synthetic α-MSH C-terminal tripeptide (Lys-Pro-Val) supplied for in-vitro inflammation and barrier-function research.
Purity
98%+ (per source specifications)
Form
Lyophilised Powder
Storage
-20°C lyophilised · store at 2–8°C once reconstituted
CAS Number
67727-97-3
Mol. Weight
342.4 g/mol
£29.99
Free UK delivery
About KPV
What it is
KPV is a tripeptide — lysine, proline, valine — corresponding to the last three amino acids of alpha-melanocyte-stimulating hormone. It is about as small as a peptide gets while still being of research interest.
How it is understood to work
The parent hormone acts on melanocortin receptors and affects pigmentation among other things. This fragment appears to retain anti-inflammatory activity while losing the pigmentary effect, and some of that activity appears to operate inside the cell rather than at a surface receptor, with work pointing to interference with NF-kappa-B signalling. Its small size is thought to help it enter cells directly.
What research has looked at
Intestinal epithelial cell models, colitis models in animals, and work on cytokine expression. It appears frequently in gut inflammation research specifically.
Handling and storage
Very small and correspondingly soluble and stable compared with longer chains. Standard storage still applies: cold, dark, and no repeated freeze-thaw.
Supplied for in-vitro laboratory research only. Nothing above describes a dose, a protocol, or a use in humans or animals, and none of these compounds is a licensed medicine in the UK.
Certificate of Analysis
Purity (HPLC)
99.3%
- Batch
- 26031605
| Test | Specification | Result |
|---|---|---|
| Appearance | White or off-white powder | Conforms |
| Identity (mass spectrometry) | 342.4 ± 1.0 | 342.0 |
| Purity (HPLC) | Not less than 98.0% | 99.3% |
| Bacterial endotoxins | Less than 5 IU/mg | Conforms |
| Water content (Karl Fischer) | Not more than 7.0% | 5.3% |
| Residual solvents | Within limits | Conforms |
This batch of KPV complies with specification. Figures are taken from the manufacturer certificate of analysis for this batch.
Research Information
KPV is a tripeptide (Lysine-Proline-Valine), the C-terminal fragment of α-MSH, studied for its role in inflammation and tissue research. Unlike its parent compound α-MSH, KPV doesn't act on melanocortin receptors but appears to enter cells directly via the PEPT1 transporter, where it interacts with intracellular inflammatory pathways. Most published work has used intestinal and skin cell lines to examine its effects on NF-κB signalling and pro-inflammatory cytokine expression.
Research areas
- NF-κB signalling pathway studies
- PEPT1 transporter research
- Inflammatory cytokine expression cell models
- Intestinal cell-line research
Analytical methods
Identity and purity are typically confirmed at source by high-performance liquid chromatography (HPLC) and mass spectrometry.
Storage and handling
Store lyophilised at -20°C, away from moisture and direct light. Once reconstituted, store at 2–8°C and use within the timeframe specified on the source datasheet.
For Research Use Only. Not for human or veterinary use.
Batch tested
Every batch is tested for identity and purity, and we publish the certificate.
UK dispatch
UK-stocked. Orders placed before 2pm dispatch the same business day via Royal Mail Tracked 24. Free UK shipping on every order. We ship to UK addresses only.