Kisspeptin-10
Synthetic decapeptide kisspeptin-10 supplied for in-vitro KISS1R receptor research.
Purity
98%+ (per source specifications)
Form
Lyophilised Powder
Storage
-20°C lyophilised · store at 2–8°C once reconstituted
CAS Number
374675-21-5
Mol. Weight
1302.5 g/mol
£17.99
Free UK delivery
About Kisspeptin-10
What it is
Kisspeptin-10 is the ten-amino-acid active fragment of kisspeptin, the product of the KISS1 gene. The gene was originally identified as a metastasis suppressor, and its name comes from Hershey, Pennsylvania, home of the chocolate — an unusually frivolous origin for a molecule that turned out to be central to reproductive biology.
How it is understood to work
It binds KISS1R, formerly known as GPR54, on hypothalamic neurons, and sits upstream of gonadotropin-releasing hormone. Its importance became clear when loss-of-function mutations in the receptor were found to cause failure of puberty, establishing kisspeptin signalling as a gatekeeper of the reproductive axis. It is a control signal several steps above the hormones it ultimately influences.
What research has looked at
Hypothalamic neuron models, reproductive endocrinology, and the regulation of puberty onset. Also studied in metabolic contexts, since the reproductive axis is sensitive to energy availability.
Handling and storage
Lyophilised, reconstitute with bacteriostatic water, refrigerate. Short peptides of this kind are typically studied at low concentrations, so accurate volumes matter.
Supplied for in-vitro laboratory research only. Nothing above describes a dose, a protocol, or a use in humans or animals, and none of these compounds is a licensed medicine in the UK.
Research Information
Kisspeptin-10 is the active 10-amino-acid C-terminal fragment of full-length kisspeptin, studied for its role in reproductive and metabolic research. Researchers are interested in how it interacts with the GPR54 (KISS1R) receptor in hypothalamic cell models — a key upstream regulator of the reproductive hormone axis. Most published work has used GnRH neuron and hypothalamic cell lines to examine kisspeptin signalling and downstream GnRH release pathways.
Research areas
- GPR54 (KISS1R) receptor binding studies
- Hypothalamic-pituitary-gonadal axis cell-model research
- GnRH release pathway studies
- Reproductive neuroendocrine research
Analytical methods
Identity and purity are typically confirmed at source by high-performance liquid chromatography (HPLC) and mass spectrometry.
Storage and handling
Store lyophilised at -20°C, away from moisture and direct light. Once reconstituted, store at 2–8°C and use within the timeframe specified on the source datasheet.
For Research Use Only. Not for human or veterinary use.
Batch tested
Every batch is tested for identity and purity, and we publish the certificate.
UK dispatch
UK-stocked. Orders placed before 2pm dispatch the same business day via Royal Mail Tracked 24. Free UK shipping on every order. We ship to UK addresses only.