AOD-9604
Synthetic HGH C-terminal fragment (residues 176–191) supplied for in-vitro metabolic-pathway and peptide-signalling research.
Purity
98%+ (per source specifications)
Form
Lyophilised Powder
Storage
-20°C lyophilised · store at 2–8°C once reconstituted
CAS Number
221231-10-3
Mol. Weight
1815.1 g/mol
£22.99
Free UK delivery
About AOD-9604
What it is
AOD-9604 is a short fragment of human growth hormone — residues 177 to 191 — with a tyrosine added at one end for stability. The logic behind it is a good example of fragment research: rather than use the whole 191-amino-acid hormone, isolate the region associated with one specific activity and leave the rest behind.
How it is understood to work
The C-terminal region of growth hormone had been associated with effects on fat metabolism in laboratory models, apparently separable from the hormone's effects on glucose handling and IGF-1 production. AOD-9604 was designed to test that separation. In adipocyte models it has been examined for effects on lipolysis and lipogenesis without the broader endocrine activity of the intact hormone.
What research has looked at
Adipocyte culture, animal models of adiposity, and work on the receptor question — notably whether it acts through the growth hormone receptor at all, which is not settled.
Handling and storage
Lyophilised. Reconstitute gently with bacteriostatic water, refrigerate, and use promptly. A short fragment is generally more robust than a full protein but still degrades in solution.
Supplied for in-vitro laboratory research only. Nothing above describes a dose, a protocol, or a use in humans or animals, and none of these compounds is a licensed medicine in the UK.
Certificate of Analysis
Purity (HPLC)
99.4%
- Batch
- 26030904
| Test | Specification | Result |
|---|---|---|
| Appearance | White or off-white powder | White powder |
| Identity (mass spectrometry) | 1815.1 ± 1.0 | 1814.6 |
| Purity (HPLC) | Not less than 98.0% | 99.4% |
| Bacterial endotoxins | Less than 10 EU/mg | Less than 5 EU/mg |
| Water content (Karl Fischer) | Not more than 8.0% | 4.2% |
This batch of AOD-9604 complies with specification. Figures are taken from the manufacturer certificate of analysis for this batch.
Research Information
AOD-9604 is a synthetic 16-amino-acid peptide representing a modified fragment of human growth hormone (hGH 176-191), studied for its role in lipid metabolism research. Researchers are interested in this fragment because it appears to retain the lipolytic (fat-mobilising) activity of native growth hormone without significantly affecting its growth-promoting pathways in cell-culture studies. Most published work has used adipocyte cell lines to examine hormone-sensitive lipase activation and downstream lipolysis.
Research areas
- Adipocyte lipolysis pathway studies
- Hormone-sensitive lipase research
- Growth hormone fragment activity comparison
- Lipid metabolism cell models
Analytical methods
Identity and purity are typically confirmed at source by high-performance liquid chromatography (HPLC) and mass spectrometry.
Storage and handling
Store lyophilised at -20°C, away from moisture and direct light. Once reconstituted, store at 2–8°C and use within the timeframe specified on the source datasheet.
For Research Use Only. Not for human or veterinary use.
Batch tested
Every batch is tested for identity and purity, and we publish the certificate.
UK dispatch
UK-stocked. Orders placed before 2pm dispatch the same business day via Royal Mail Tracked 24. Free UK shipping on every order. We ship to UK addresses only.