5-Amino-1MQ
Synthetic small-molecule NNMT inhibitor supplied for in-vitro NAD+ metabolism research.
Purity
98%+ (per source specifications)
Form
Solid powder
Storage
-20°C lyophilised · store at 2–8°C once reconstituted
£39.99
Free UK delivery
About 5-Amino-1MQ
What it is
5-Amino-1MQ is not a peptide at all but a small molecule, which makes it an outlier in this catalogue. It is a methylquinolinium compound developed as an inhibitor of nicotinamide N-methyltransferase, usually shortened to NNMT.
How it is understood to work
NNMT consumes nicotinamide, a precursor in the salvage pathway cells use to regenerate NAD+. Inhibiting the enzyme is of research interest because it leaves more nicotinamide available to that pathway, so the molecule is studied as a way of nudging NAD+ availability indirectly rather than supplying NAD+ itself. NNMT is expressed particularly heavily in adipose tissue and liver, which is where most of the work has concentrated.
What research has looked at
Adipocyte cell culture, NAD+ salvage pathway kinetics, and metabolic models in animals. The enzyme has also drawn attention in cancer biology, where its expression is elevated in several tumour types.
Handling and storage
A small molecule rather than a peptide, so the usual peptide fragility rules do not apply in the same way. Store cool and dry, protected from light. Solubility differs from the peptides here — check what your protocol requires rather than assuming bacteriostatic water.
Supplied for in-vitro laboratory research only. Nothing above describes a dose, a protocol, or a use in humans or animals, and none of these compounds is a licensed medicine in the UK.
Certificate of Analysis
Purity (HPLC)
99.28%
- Batch
- J-NI60-202509003
| Test | Specification | Result |
|---|---|---|
| Appearance | Brown to brownish-red powder | Conforms |
| Purity (HPLC) | Not less than 98.0% | 99.28% |
| Assay | 98.0% - 102.0% | 100.07% |
| Related substances (single impurity) | Not more than 1.0% | 0.72% |
| Heavy metals | Not more than 20 ppm | Conforms |
| Water content | Not more than 8.5% | 4.5% |
This batch of 5-Amino-1MQ complies with specification. Figures are taken from the manufacturer certificate of analysis for this batch.
Research Information
5-Amino-1MQ is studied for its role in cellular metabolism research. It's a small-molecule inhibitor of NNMT — an enzyme involved in how cells handle methyl groups and store energy. Researchers are interested in NNMT because the pathway has been linked to fat storage, energy expenditure, and metabolic flexibility in cell-culture studies. Most published work has used in-vitro adipocyte models to examine how blocking NNMT affects lipid storage and mitochondrial activity.
Research areas
- NNMT enzyme inhibition studies
- Adipocyte cell-line research
- Methyl-donor metabolism pathway studies
- Mitochondrial activity in metabolic cell models
Analytical methods
Identity and purity are typically confirmed at source by high-performance liquid chromatography (HPLC) and mass spectrometry.
Storage and handling
Store at -20°C, away from moisture and direct light. Solid powders should be brought to room temperature in a desiccator before opening to avoid moisture condensation.
For Research Use Only. Not for human or veterinary use.
Batch tested
Every batch is tested for identity and purity, and we publish the certificate.
UK dispatch
UK-stocked. Orders placed before 2pm dispatch the same business day via Royal Mail Tracked 24. Free UK shipping on every order. We ship to UK addresses only.